Fig 1.
Venn diagram of the number of loci significant using HapMap (left circle) and 1000G (right circle) imputation in A) the main analysis, B) the sensitivity analysis applying a significance threshold of 2.5×10−8 to the 1000G GWA analysis, C) the sensitivity analysis without using genomic control corrections, and D) the sensitivity analysis excluding studies that used different imputation software, analysis software, or covariates in the HapMap and 1000G GWA analyses.
Table 1.
Non-overlapping loci that were significant in either the HapMap or 1000G GWA studies.
Table 2.
Overlapping loci that were significant in both the HapMap and 1000G GWA studies.
Fig 2.
Summary of the differences between HapMap and 1000G imputation for the seven non-overlapping loci.
Fig 3.
Regional plots of non-overlapping loci that were more significantly associated with fibrinogen in the 1000G GWA study, including variants from both the HapMap (red) and 1000G (green) GWA studies.
Fig 4.
Regional plot of 6p21.3, a non-overlapping locus that was more significantly associated with fibrinogen in the HapMap GWA study, including variants from both the HapMap (red) and 1000G (green) GWA studies.
Fig 5.
Summary of the differences between HapMap and 1000G imputation for the 29 overlapping loci.