Fig 1.
Schematic illustration of a tooth with a healthy pulp (left panel) and an inflamed pulp (right panel) subjacent to a caries lesion.
Involved factors and biological effectors are indicated for both pulpal conditions.
Fig 2.
PRISMA flowchart depicting the systematic selection and exclusion of articles related to the topic.
A detailed description of the excluded articles with the respective reasons for exclusion is presented in the running text and S4 Table. From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Iterns for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(7): e1000097. doi: 10.1371/journal.pmed1000097 For more information, visit www.prisma-statement.org.
Table 1.
Studies assessing pulp tissue for the presence of biomarkers associated with pulpal condition.
Table 2.
Studies assessing other substrates than pulp tissue for the presence of a biomarker.
Fig 3.
Bar chart showing the quality ratings of the included studies based on a modified Newcastle-Ottawa-Scale.
Fig 4.
Actual and potential sampling sites to assay pulpal mediators.