Table 1.
Clinical characteristics of three Danish study populations included into the analysis.
Table 2.
Associations between body fat% GRS and CRF expressed in VO2max (ml/kg/min), VO2maxFFM (ml/kg FFM/min) as well as VO2maxFM (ml/kg FM/min) after meta-analysis of two Danish cohorts (ADDITION-PRO (n = 716) and Health2006 (n = 2490)).
Fig 1.
Association between the body fat% GRS and body fat% in the low CRF and high CRF groups after meta-analysis of two Danish cohorts (ADDITION-PRO and Health2006, a total n = 3206).
Weighted mean body fat% for each number of body fat% risk alleles was calculated based on the relative weight for each cohort. CRF was objectively measured by step test and the study participants of both cohorts were stratified by the respective median of VO2max to form “high CRF” and “low CRF” groups. We tested for body fat% GRS x CRF interaction effects using linear models (Pinteraction = 0.03).
Table 3.
Associations between the FTO rs1558902 A-allele and VO2max (ml/kg/min), VO2maxFM (ml/kg FFM/min) as well as VO2maxFFM (ml/kg FM/min) after meta-analysis of two Danish cohorts (ADDITION-PRO (n = 716) and Health2006 (n = 2586)), assuming a fixed effect model.