Fig 1.
Flowchart of patient enrollment.
Table 1.
Characteristics of the study cohort.
Table 2.
Cognitive profile of the study cohort.
Table 3.
Relation between WMH volume within 11 white matter tracts and executive functioning, visuomotor speed and memory.
Fig 2.
Lesion prevalence map and voxel-based lesion-symptom mapping results.
(A) Lesion prevalence map. Voxels with white matter lesions in at least 10 patients are projected onto the MNI-152 template. (B-C): VLSM results for executive functioning (panel B), visuomotor speed (panel C) and memory (panel D) after correction for age, sex, level of education and multiple testing (settings: BM-test; FDR q<0.05). Significant voxels are shown in red. Z-coordinates: -20, -10, 0, 10, 20, 30, 40, 50. (E-F) VLSM results for executive functioning (panel E; coordinate Z-17) and visuomotor speed (panel F; coordinate Z-16) after additional correction for total WMH volume and presence of lacunes. One representative slice is shown per cognitive domain that depicts the location of several significant voxels (in red) in relation to the forceps minor (blue) and anterior thalamic radiation (green). The location of all significant voxels are provided in Table 4.
Table 4.
Voxel-based lesion-symptom mapping results: tested and significant voxels for each anatomical region, after additional correction for total WMH volume and the presence of lacunes.
Table 5.
Comparison of the impact of total WMH volume, regional WMH volume and brain atrophy on executive functioning, visuomotor speed and memory.
Table 6.
Sensitivity analysis, restricted to patients without a diagnosis of AD (n = 125).