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Table 1.

Demographic and health-related characteristics of the Washington D.C. prostate cancer study by outcome.

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Table 2.

Crude and adjusted prostate cancer estimates.

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Table 2 Expand

Fig 1.

Flow diagram of systematic literature search on zinc and the risk of prostate cancer.

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Table 3.

Characteristics of papers included in the meta-analysis.

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Table 3 Expand

Fig 2.

Forest plot of included studies for the highest versus lowest meta-analysis, stratified by zinc intake (dietary, supplement, and total) or zinc status (serum, nail, and hair).

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Fig 2 Expand

Fig 3.

Funnel plot of studies examining the association between zinc and prostate cancer incidence as a test for publication bias.

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Fig 4.

Sensitivity analysis investigating the influence of each individual study on the overall meta-analysis of zinc and risk of prostate cancer.

The meta-analysis of all studies except the “omitted” study named on the left margin is presented as a horizontal confidence interval. The full, “combined” results are shown as the solid vertical lines.

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Table 4.

Summary of the meta-analyses for the association of zinc and prostate cancer.

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Table 4 Expand

Fig 5.

Dose-response relations between zinc intake and RR of prostate cancer (P for nonlinearity = 0.0022).

The fitted nonlinear trend is represented by the solid line with the 95% confidence intervals line in long dashes. Lines with short dashes represent the linear trend.

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Fig 5 Expand