Table 1.
Patient Characteristics Stratified by BMI.
Transplant recipient demographics frequencies were stratified by BMI. Abbreviations: AfAm: African American, AmIndian = American Indian, SCD = standard criteria donor, ECD = expanded criteria donor; Diabetes I = Type I diabetes, Diabetes II = Type II diabetes, CAD = coronary artery disease, PVD = peripheral vascular disease.
Table 2.
Adverse Outcomes Stratified by BMI.
The number and percentage of transplant recipient outcomes (DGF, acute rejection, urine protein and graft failure) stratified by BMI and assessed for significant differences across BMI categories by chi square using SAS 9.3. Outcomes of all kidney donor types (deceased and living) are shown on top, and outcomes of living kidney donors shown on bottom. p<0.05 is significant.
Table 3.
Adverse Outcomes Relative to Normal BMI.
Adverse outcomes of DGF, AR, urine protein relative to normal BMI were calculated using logistic regression analysis. The logistic regression model is adjusted for ethnicity, gender, age, graft type, comorbidities (e.g., diabetes). Odds ratio (OR) outcomes and 95% Confidence intervals (CI) are featured. p<0.05 is significant.
Fig 1.
Time to Graft Failure Stratified by BMI.
Median Time to graft failure for each BMI category was determined by analyzing the time difference (in days) between date of graft failure and date of transplant. Living donors (black bars), all donors (white bars). p-value < 0.05 is statistically significant.
Fig 2.
Effect of BMI on Graft Failure is Independent of Diabetes Mellitus.
Life-table survival curves were plotted to describe the median time-to-failure for all donor types in recipients with diabetes (Fig 2a) or without diabetes (Fig 2b) for each BMI category and log-rank tests were used to compare them. Time to failure spans 0 was restricted to (time of transplant) to 8000 days (21.9 years). p<0.05 is significant. With calculated p<0.0001 for both +/- diabetes cohorts.
Fig 3.
Increasing BMI of Transplant Recipients by Time Period.
Temporal trends of BMI in transplant recipients stratified by BMI (<18.5, 18.5–24.9, 25–29.9, 30–34.9, 35–39.9, 40+) for each time period of transplantation (<2000, 2001–2004, 2005–2008, 2009+) tabulated for all donors (left) and living donors (right). Significance across BMI for each time period of transplantation was determined by chi square. p<0.05 is significant.
Fig 4.
Graft Survival Stratified by BMI for Time Periods <2000, 2001–2004, 2005–2008.
Survival rates are shown for 3000 days for each time period of transplantation (<2000, 2001–2004, 2005–2008) stratified for each BMI category.