Table 1.
Pre-OP Cut-Off-Levels (PDR & R15), Patient demographics, outcome- and laboratory parameters.
Table 2.
POD 1 Cut-Off-Levels (PDR & R15), Patient demographics, outcome- and laboratory parameters.
Fig 1.
Perioperative ICG-Clearance Time Course.
ICG-clearance was measured 1 day prior to surgery (Pre OP), on the first postoperative day (POD 1) and five days (POD 5) after liver resection. The perioperative time course of ICG plasma diffusion rate (PDR [A]) and retention rate after 15 minutes (R15 [B]) is illustrated and shown separately according to the extent of resection (PDR = C, R15 = D). Boxplot illustrations are given without outliers and extreme values to improve the resolution of interquartile ranges. * P <0.05, ** P <0.005.
Fig 2.
Perioperative ICG-Clearance According to Postoperative LD and Morbidity.
ICG (Indocyanine Green)-clearance was measured 1 day prior to surgery (pre OP), on the first postoperative day (POD 1) and on the fifth postoperative day (POD 5). Patients were divided in groups with or without postoperative liver dysfunction (plasma diffusion rate [PDR = A], retention rate at 15 minutes [R15 = B]) and severe morbidity (PDR = C, R15 = D). Boxplot illustrations are given without outliers and extreme values to improve the resolution of interquartile ranges. * P <0.05, ** P <0.005.
Fig 3.
Perioperative ICG—Clearance According to Severity of Postoperative LD.
Indocyanine Green (ICG)-clearance was measured 1 day prior to surgery (pre OP), on the first postoperative day (POD 1) and five days after liver resection (POD 5). ICG plasma diffusion rate (PDR [A]) and ICG retention rate at 15 minutes (R15 [B]) are illustrated according to severity of postoperative liver dysfunction (LD) according to International Study Group of Liver Surgery (ISGSL) criteria. * P <0.05, ** P <0.005.
Table 3.
Pre-OP Levels (LD & Hepatic Resection), Patient demographics, outcome- and laboratory parameters.
Fig 4.
Preoperative ICG-Clearance and Prediction of Postoperative Outcome.
Receiver operating characteristic (ROC)- curve analysis for preoperative ICG (Indocyanine Green)–clearance to predict postoperative liver dysfunction (LD) is illustrated (plasma diffusion rate [PDR = A], retention rate at 15 minutes [R15 = B]). The incidence of postoperative LD (PDR = C, R15 = D) as well as of severe postoperative morbidity (PDR = E, R15 = F) is shown according to the defined cut-off values for preoperative ICG-Clearance (PDR <17, R15 >8). * P <0.05, ** P <0.005.
Table 4.
Perioperative ICG-Clearance.
Table 5.
Clinical Outcome Parameters.
Fig 5.
Postoperative ICG—Clearance and Prediction of Postoperative Outcome.
Receiver operating characteristic (ROC)- curve analysis for ICG (Indocyanine Green)–clearance on postoperative day one (POD 1) to predict postoperative liver dysfunction (LD) is illustrated (plasma diffusion rate [PDR] = A, retention rate at 15 minutes [R15] = B). The incidence of postoperative LD (PDR = C, R15 = D,) as well as of severe postoperative morbidity (PDR = E, R15 = F) is shown according to the defined cut-off values for ICG-clearance on POD 1 (PDR <10, R15 >20). * P <0.05, ** P <0.005.