Table 1.
Targets and functions of selected miRNAs.
Table 2.
Overview of the study population.
Fig 1.
MiRNA expression in age groups.
Box plots of relative miRNA expression levels in plasma of lung cancer patients divided into three age groups: <60 years, 60–70 years, >70 years. The expression levels of miRNAs were normalized to miR-16 using dCq method. *P = 0.004; **P = 0.007 (One-way ANOVA).
Fig 2.
Box plots of relative miRNA expression levels in plasma of lung cancer patients and healthy individuals. The expression levels of miRNAs were normalized to miR-16 using dCq method. (А) Lung cancer patients (LC) and healthy individuals (HD); (B) Squamous cell carcinoma (SCC), adenocarcinoma (AD) patients and healthy individuals (HD). P-values obtained by T-test (two-sided) or Welch-test (two-sided).
Fig 3.
ROC analysis of miRNA expression.
Receiving Operator Characteristic (ROC) curves for individual miRNAs and combination of miR-19b and miR-183. (A)–(E) Individual miRNAs; (F) Binary logistic regression of miR-19b and miR-183. ROC curves discriminate squamous cell carcinoma (SCC), adenocarcinoma (AD) and total study population of lung cancer patients (LC) from healthy individuals (HD).
Fig 4.
Survival analysis of LC patients.
Kaplan-Meier survival analysis of lung cancer patients. (A)–(D) Expression of miRNAs and survival of lung cancer patients. The ‘High’ and ‘Low’ miRNA expression groups were delimited by group median dCq value for each miRNA.