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Fig 1.

Flow diagram of enrollment.

TB: tuberculosis, QFT: QuantiFERON-TB Gold In-Tube, TST: Tuberculin Skin Test.

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Table 1.

Descriptive analysis and comparisons between the results of the QFT and the TST test in children up to 6 years of age in Manaus, Brazil.

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Table 1 Expand

Table 2.

Results of the prevalence of LTBI according to exposure to an index TB case and the sensitivity and the specificity of QFT and TST in children up to 6 years of age in Manaus, Brazil (first phase).

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Table 2 Expand

Table 3.

Probability of LTBI in children up to 6 years of age according to the results of both tests in the latent class model (first phase).

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Table 3 Expand

Table 4.

Probability of non LTBI (LTBIc) in children up to 6 years of age according to the results of both tests in the latent class model (first phase).

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Table 5.

Estimation of the sensitivity and specificity of QFT and TST, and the coefficients of regression of the variables of time of exposure and MTC-Score associated with the prevalence (second phase).

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Fig 2.

Prevalence of LTBI according to the time of exposure of 0, 1, 3, 6 and 12 months and the MTC-score values of 4, 8, 13 and 15 in children up to 6 years of age in Manaus, Brazil.

MTC-SCORE: Mycobacterium tuberculosis contact score.

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Fig 2 Expand

Fig 3.

Positive and negative predictive values for QFT for times of exposure of 1, 3, 6, and 12 months and intensity of exposure of 4, 8, 13 and 15.

TST: Tuberculin Skin Test, QFT: QuantiFERON-TB Gold In-Tube, PPV: positive predictive values, NPV: negative predictive values.

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Fig 3 Expand