Fig 1.
A comparison of this study data and INTERGROWTH 21st standards.
Longitudinal measurements of abdominal circumference (AC) (top left), head circumference (HC) (top right), biparietal diameter (BPD) (bottom left), and femur length (FL) (bottom right), as well as 90% confidence intervals, derived from both the Hutzel population used in this study (red) and the INTERGROWTH-21st study (blue).
Table 1.
Demographic characteristics of the studied cohort.
Fig 2.
SGA and LGA prediction performance for the entire study population.
Sensitivity of predicting small-for-gestational–age (SGA; <5th percentile) (left) and large-for-gestational–age neonates (LGA; >95th percentile) (right) for multiple GA cutoffs. Bars show sensitivity at a 10% false positive rate when using data up to a given GA cutoff (x-axis) to predict the outcome of infants delivered after that cutoff. The number of controls/cases based on which sensitivity is estimated is given under each cutoff. Blue bars correspond to single biometry analysis (last available sample) while red bars are used for longitudinal analysis. * denotes a significant difference in sensitivity for the given cutoff (p<0.05).
Fig 3.
SGA and LGA prediction performance for a restricted study population.
Sensitivity of predicting small-for-gestational–age (SGA; <5th percentile) (left) and large-for-gestational–age neonates (LGA; >95th percentile) (right) for multiple GA cutoffs when restricting analysis to subjects with the last measurement before each cutoff within two weeks from the cutoff.
Table 2.
Distribution of gestational ages at the final evaluation before each gestational age cutoff.
Fig 4.
Estimated fetal weight Z-scores as a function of gestational age at delivery and outcome.
Estimated fetal weight Z-scores for the last available sample at ≤32 weeks of gestation for all pregnancies (top) and those with the last sample between 30 and 32 weeks (bottom) as a function of gestational age at delivery. Horizontal lines denote the Z-score cutoff that leads to a false positive rate of 10% for each outcome (small- or large-for-gestational-age newborns) separately.