Fig 1.
Optical coherence tomography (OCT) image sets.
OCT image sets were obtained using a raster scan protocol on a spectral domain OCT system (3D OCT-1000 Mark II, Topcon, Japan).
Fig 2.
UK Biobank Data Processing Scheme.
The source data (optical coherence tomography (OCT) image sets) were stored on a central repository and accessed via remote, secure login.
Fig 3.
Automated Segmentation of Optical coherence tomography (OCT) image sets.
Topcon Advanced Boundary Segmentation (TABSTM) software was used to perform automated segmentation of nine intraretinal boundaries. in a rapid fashion. Boundary 7 has previously been described as the inner aspect of the photoreceptor inner segment-outer segment junction (and is still described as this by Topcon Inc.); however, in a recent proposed nomenclature for classification of retinal layers on OCT, this boundary is referred to as the photoreceptor ellipsoid zone.[22]