Fig 1.
Flowchart of included patients.
142 patients were not screened due to exclusion criteria (sarcoidoses, tuberculosis or already on vitamin D treatment) or if they were not planned to be followed at the clinic for at least one year or if they for other reasons were considered not suitable for participating in a trial. 111 were excluded due to 25 OH D-levels above 75 nmol/L and 6 declined to participate (excluded n = 117). One patient died during the study period (lost to follow up) and was therefore excluded from the final analysis.
Table 1.
Diagnoses in the study cohort.
CVID, Common Variable Immuno-Deficiency. ‘IgG Suppl’, number of patients with Immunoglobulin supplementation.
Table 2.
Antibiotic consumption and 25-hydrovitamin D levels in the whole study cohort and in the different subgroups before and after 1 year of vitamin D3 supplementation.
Fig 2.
Number of days with antibiotics (A) and number of prescriptions (B) per patients the year before and after starting on vitamin D treament. The lines shows median and boxes show interquartile range. Statistical test was performed using Wilcoxon matched-pairs signed rank test.
Fig 3.
Days with antibiotics for each patient (n = 277) the year before and after starting on vitamin D treament in the study cohort.
Vitamin D supplementation resulted in more patients that could be without antibiotics during the year, the number of patients with no antibiotics increased from 52 to 81; Fischer exact test showed OR 1.79; 95% CI 1.20–2.66 (p<0.01).
Table 3.
Type of Antibiotics prescribed the year before and after starting vitamin D supplementation.