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Fig 1.

Participant flow.

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Table 1.

Baselines characteristic of participants.

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Table 1 Expand

Table 2.

Japanese Knee Osteoarthritis Measure (JKOM) scores before and after administration.

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Table 2 Expand

Table 3.

Japanese Orthopaedics Association (JOA) scores before and after administration.

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Table 3 Expand

Table 4.

Changes in Japanese Knee Osteoarthritis Measure (JKOM) score.

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Table 4 Expand

Table 5.

Changes in Japanese Orthopaedics Association (JOA) score.

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Table 5 Expand

Table 6.

Blood and urine parameters before and after administration.

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Table 6 Expand