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Table 1.

Baseline Demographic and Laboratory data.

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Fig 1.

Scatter Plot and Regression Line Between Flow-Mediated Dilation and Albuminuria in Sickle Cell Anemia: Urine albumin-creatinine ratio is significantly correlated with FMD (ρ = -0.45; 95% CI: -0.72 –-0.04, p = 0.031).

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Fig 2.

Distribution of Flow-Mediated Dilation by Albuminuria Categories: FMD is lowest in patients with severely increased albuminuria compared with those with moderately increased and normal albuminuria, although the difference is not statistically significant (p = 0.16).

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Table 2.

Values of Measures of Endothelial Function Based on Albuminuria Category.

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Table 2 Expand

Table 3.

Levels of Biological Variables Based on Albuminuria Category.

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Table 3 Expand

Table 4.

Spearman Correlation of Urine Albumin-Creatinine Ratio with Biological Variables.

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Table 4 Expand

Table 5.

Spearman Correlation of Flow Mediated Dilation with Biological Variables.

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Table 5 Expand

Fig 3.

Scatter Plot and Regression Line Between Spot Urine Albumin-Creatinine Ratio and 24-Hour Urine Protein: Urine albumin-creatinine ratio is strongly correlated with total urinary protein assessed by 24-hour urine collection (ρ = 0.90; 95% confidence interval [CI]: 0.75–0.95, p < 0.0001).

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Fig 3 Expand

Fig 4.

Scatter Plot and Regression Line Between Spot Urine Albumin-Creatinine Ratio and Urine Aliquot for Albumin-Creatinine Ratio: Urine albumin-creatinine ratio assessed by spot albumin-creatinine ratio is strongly correlated with urine aliquots for albumin-creatinine ratio obtained from the 24-hour urine collection (ρ = 0.97; 95% CI: 0.92–0.99, p < 0.0001).

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Fig 4 Expand