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Fig 1.

The trial profile.

The Participant flow is shown.

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Table 1.

Baseline characteristics.

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Fig 2.

Results of analyses of the primary and secondary endpoints.

A: The recurrence-free survival curves of the UFT/LV group (red line) and surgery alone group (black line) group are shown. The 3-year recurrence-free rate was significantly higher in the UFT/LV group than in the surgery alone group (38.6% vs. 32.3%, P = 0.003). B: The overall survival curves of the two groups are shown. The 5-year overall survival rates of the two groups were similar (66.1% vs. 66.8%, P = 0.409).

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Fig 2 Expand

Fig 3.

Results of subgroup analyses.

A: The recurrence-free survival curves of the UFT/LV group (red line) and surgery alone group (black line) are shown for patients with a single liver metastasis. B: The recurrence-free survival curves of the two groups are shown for patients with multiple liver metastases. C: The recurrence-free survival curves of the two groups are shown for patients with synchronous liver metastases. D: The recurrence-free survival curves of the two groups are shown for patients with metachronous liver metastases.

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Fig 3 Expand

Table 2.

Locations and treatments of first recurrence.

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Table 2 Expand