Table 1.
Demographic and clinical characteristics of participants (mean ± SD).
Fig 1.
Representation of the five striatal seed regions.
The left sagittal brain shows the locations of the three caudate seeds: inferior ventral striatum (VSi), superior ventral striatum (VSs), and dorsal caudate (DC). The right shows the locations of the two putamen seeds: dorsal putamen (DP) and ventral putamen (VP).
Fig 2.
Regions showing significant functional connectivity with the striatal seeds in PD OFF compared with normal control subjects (two-sample t test, P <0.05, AlphaSim, K ≥85 voxels).
Fig 3.
Regions showing significant functional connectivity with the striatal seeds in PD ON compared with PD OFF (two-sample t test, P <0.05, AlphaSim, K ≥85 voxels).
The regions were overlaid on anatomical images from a representative subject of the MNI series. “Hot” colors indicate increased correlation strength in PD ON and “Cold” colors indicate decreased correlation strength in PD ON relative to PD OFF. VCi, inferior ventral striatum; VCs, superior ventral striatum; DC, dorsal caudate; VP, ventral putamen; DP, dorsal putamen.
Table 2.
Significant connectivity difference between PD OFF and PD ON.
Fig 4.
Regions showing greater connectivity with ventral striatal seeds (VCi, VCs, and VP combined) than with dorsal striatal seeds (DC and DP combined) in “Cold” and regions showing greater connectivity with dorsal striatal seeds than with ventral striatal seeds in “Hot” (P <0.001, AlphaSim, K ≥6 voxels).
Table 3.
Direct comparisons between ventral striatum seeds combined and dorsal striatum seeds combined.
Fig 5.
Regions showing greater connectivity with ventral striatal seeds (VCi, VCs, and VP combined) and with dorsal striatal seeds (DC and DP combined) in PD ON than PD OFF in “Hot”; Regions showing greater connectivity with ventral striatal seeds and with dorsal striatal seeds in PD OFF than PD ON in “Cold” (P <0.05, AlphaSim, K ≥85 voxels).
Table 4.
Significant connectivity difference between PD on medication and PD off medication.