Fig 1.
Baseline measurements including refractive errors (Rx), axial length (AXL) and OCT images were taken after cycloplegia. Subjects were randomly assigned into control, myopic defocus or hyperopic defocus group and defocus lenses were worn for 2 hours using trial lenses. Defocus lenses were then removed after 2 hours of lens wear. AXL and OCT images were acquired every hour.
Fig 2.
A representative OCT image showing choroid using enhanced depth imaging (EDI) mode.
Subfoveal choroidal thickness was determined manually by two independent experienced observers using built-in software.
Table 1.
Baseline data (mean ± SEM) in control, myopic defocus and hyperopic defocus group.
Fig 3.
Changes in subfoveal choroidal thickness (SFChT) and axial length (AXL) in response to optical defocus.
Percentage change vs. baseline in SFChT (A) and AXL (B) in control group (CG), myopic defocus group (MDG) and hyperopic defocus group (HDG) during the study. DF1h and DF2h denote 1 and 2 hours after receiving optical defocus, respectively. RE1h and RE2h denote 1 and 2 hours after removing the optical defocus, respectively. Data shown are in mean ± SEM, * p < 0.05, ** p < 0.01, two-way ANOVA.
Table 2.
Changes in axial length and subfoveal choroidal thickness (SFChT) in response to control, myopic and hyperopic defocus.