Table 1.
Allelic and genotypic associations of SNP rs2107595 with CAD risk.
Table 2.
Subtype and subgroup analyses for the association between SNP rs2107595 and CAD risk.
Table 3.
Association of SNP rs2107595 with the severity of coronary atherosclerosis in 2317 CAD patients under a dominant model.
Table 4.
The gene-environment interactions between SNP rs2107595 and conventional CAD risk factors in CAD risk and the severity of coronary atherosclerosis by MDR analyses.
Fig 1.
Interaction entropy graphs for the gene-environment interactions between SNP rs2107595, BMI status, and histories of T2DM and hyperlipidemia in CAD risk and the severity of coronary atherosclerosis.
(A)Interaction entropy graphs for the gene-environment interactions between SNP rs2107595, BMI status, and histories of T2DM and hyperlipidemia in CAD risk; (B)Interaction entropy graphs for the gene-environment interactions between SNP rs2107595, BMI status, and histories of T2DM and hyperlipidemia in the severity of coronary atherosclerosis. In these graphs, the univariate effect of each variable and the pairwise interactions are expressed as the percentage of entropy. The univariate effect of each variable is presented in a box with the percentage of entropy. The pairwise interactions are shown as connected lines accompanied by the percentage of entropy. Different colors on lines indicate the strength of the interactions, i.e. red, orange and yellow lines mean strong, moderate and weak interactions, respectively.
Table 5.
Associations of SNP rs2107595 with HDAC9 mRNA expression and plasma HDAC9 levels.
Fig 2.
Associations of SNP rs2107595 with HDAC9 mRNA expression and plasma HDAC9 levels.
(A) Associations of SNP rs2107595 with HDAC9 mRNA expression in controls and patients with NSTEMI and STEMI; (B) Associations of SNP rs2107595 with plasma HDAC9 levels in controls and patients with NSTEMI and STEMI. ANCOVA models are used to assess statistical significance. Data are expressed as mean ± standard deviation (SD).