Fig 1.
Search results.
Fig 2.
Results of assessment of risk of bias.
Green–Low risk of bias, Red–High risk of bias, Amber–Unclear risk of bias.
Table 1.
Results of RCTs comparing aminophylline to placebo *Loading doses altered based on the results of TDM.
ASS asthma severity score, CAS/PI clinical asthma score/pulmonary index.
Table 2.
Results of RCTs comparing aminophylline to β2 adrenergic agonist.
Fig 3.
Quantitative synthesis of studies comparing aminophylline to placebo.
Dose Regimens: Digiulio 1993 6mg/kg bolus 0.8–1.0mg/kg/h infusion, Ream 2001 7mg/kg bolus 0.5–0.8mg/kg/h infusion, Needleman 1995 6-8mg/kg bolus 0.8–1.0mg/kg/h infusion, Carter 1993 loading dose calculated on TDM infusion 0.8–1.0mg/kg/h, D’Aliva 2008 2 x 5mg/kg bolus, Strauss 1994 7mg/kg/h bolus 0.75 to 1.2 infusion