Fig 1.
Lesion incidence map of patients with stroke.
The coloured bar denotes the lesion incidence. R, right; L, left.
Table 1.
Demographic and clinical data of healthy control subjects and stroke patients.
One-way analysis of variance (ANOVA) for continuous variables among the three groups. Chi-square test for categorical variables.
Table 2.
Neuropsychological characteristics of healthy control subjects and stroke patients.
Data are presented as means ± SD. MoCA: Montreal Cognitive Assessment; AVLT: Auditory Verbal Learning Test; TMT-A: Trail Making Test, Part A; TMT-B: Trail Making Test, Part B; CFT: Complex Figure Test; DST-F: Forward Digit Span Test; DST-B: Backward Digit Span Test; SDMT: Symbol Digit Modalities Test.
Fig 2.
Group-level analyses of the ReHo patterns.
(A) HC: healthy controls; (B) PSGC: stroke patients with good cognitive function; (C) PSPC: stroke patients with poor cognitive function. T = results from one-sample tests; X, Y, and Z = x, y, and z Montreal Neurological Institute (MNI) coordinates, respectively. R, right; L, left.
Fig 3.
One-way ANOVA and post hoc ReHo analysis results.
(A): Detailed regions in the images show differences in ReHo within the DMN between the three groups. (B) and (C): Detailed regions in the images show decreased ReHo in (B) PSPC patients compared to PSGC patients and (C) PSPC patients compared to HC. F = results from ANOVA; T = results from two-sample t-test; X and Z = x and z Montreal Neurological Institute (MNI) coordinates, respectively; R, right; L, left.
Table 3.
Brain regions showing significantly different ReHo between the two groups of post subcortical stroke patients and the healthy control group (ANOVA).
Comparisons were performed at P < 0.01, AlphaSim-corrected; MNI, Montreal Neurological Institute; R, right; L, ACC: Anterior cingulate cortex; PCC: Posterior cingulate cortex.
Table 4.
Results of post hoc analyses based on two-sample t-tests between the PSPC group and the other two groups (PSGC and HC).
ACC: Anterior cingulate cortex. Comparisons were performed using a significance threshold of P < 0.01, AlphaSim-corrected; MNI, Montreal Neurological Institute; R, right; L, left.
Fig 4.
Scatterplot showing the significant positive correlations between the neuropsychiatric data and the ReHo indexes of the ACC and PCC/precuneus in all stroke patients.
(A) The ReHo of the bilateral ACC positively correlated with the SDMT scores and (B) CFT-delay recall subtest scores in all stroke patients. (C) The ReHo of the left PCC/precuneus positively correlated with the DST-F test scores in all stroke patients.