Table 1.
Cause of death of 582 people with MS, UKMSTB January 1998 to February 2015.
Fig 1.
Cox proportional hazard regression model comparing disease length leading to MS-related deaths and unrelated deaths.
Those whose death was MS-related had a shorter disease course from symptom onset to death than those whose death was unrelated (R2 = 0.016, n = 504, p<0.01; MS death 1.32, 95CI 1.08–1.61). Dotted line represents MS-related deaths; solid line represents non-MS-related deaths.
Fig 2.
Cox proportional hazard regression models of disease milestones in those who progressively dwindle compared to other trajectories.
Those who progressively dwindle had an earlier age at onset (A, R2 = 0.02, n = 504, p<0.01; Progressive dwindling: 1.08, 95CI 1.03–1.14), progression (B, R2 = 0.024, n = 390, p<0.01; Progressive dwindling: 1.09, 95CI 1.03–1.16), wheelchair use (C, R2 = 0.022, n = 462, p<0.01; Progressive dwindling: 1.09, 95CI 1.03–1.15) and death (D, R2 = 0.014, n = 582, p<0.01; Progressive dwindling: 1.07, 95CI 1.02–1.12). Dotted lines represent those with progressive dwindling trajectory to death; solid line represents all other disease trajectories.
Table 2.
Different Trajectories association with MS milestones.
Table 3.
Community vs. hospital and trajectory to death.
Table 4.
The relationship between place of death and whether a death was MS-related.