Table 1.
Patient characteristics.
Table 2.
Correlations between IVIM-metrics and DSC-MRI parameters for CER and NCERa.
Fig 1.
Glioblastoma in a 62-year-old woman.
(A) Axial FLAIR image. (B) Contrast-enhanced T1-weighted image shows a rim-enhancing tumor. (C) Cerebral blood flow map obtained with DSC-MRI shows hyperperfusion signals predominantly in the left margin of the tumor (arrows). (D) DSC cerebral blood volume map. The hyperperfusion signal intensities correlate with those seen on cerebral blood flow map. (E) f map clearly highlights the area with high perfusion in the margins of the tumor (arrows), which is more evident than in C and D. (F) D map shows small restricted diffusion area (average D value = 0.895 x 10−3 mm2/s) predominantly in the anterior tumor margin (arrows). (G) D* map shows increased fast-diffusion values in the tumor tissue (arrows).
Table 3.
Clinical data, and diffusion and perfusion parameters in contrast-enhancing and non-enhancing regions according to survivala.
Table 4.
Survival prediction: summary of class performance and hazard ratios for associations between imaging features and overall survivala.
Fig 2.
Boxplots of DSC-MRI parameters and IVIM-metrics for CER according 6-month survival.
Fig 3.
Kaplan-Meier survival curves comparing survival rates for treatment and for pre-specified cutoff values of fCER and D*CER (upper row) and for these cutoffs according to treatment received (lower row) Surgery, radiotherapy, and chemotherapy with concomitant and adjuvant temozolomide was considered standard treatment (tx).