Fig 1.
Summary of the Work Process of the Prospective iACT Service.
Combination antibiotic regimens recommended by the iACT service take into account both the in vitro bactericidal activity of the combinations and the probability of PK/PD target attainment, and are recommended to the attending ID physician within 48h from request. Abbreviations used in Fig 1: GNB = Gram-negative bacteria, iACT = in vitro antibiotic combination testing, ID = Infectious Diseases, MIC = minimum inhibitory concentration PDR = pan-drug resistant, PK = pharmacokinetic, XDR = extensively-drug resistant.
Table 1.
Simulated Antibiotic Dosing Regimens and Corresponding Drug Concentrations.
Table 2.
Demographics and Clinical Features of Patients Receiving in Vitro Combination Antibiotic Testing Guided Therapy (No. of cases = 39).
Table 3.
Description of In Vitro Antimicrobial Susceptibility and MIC ranges of XDR- or PDR-GNB (20 Strains of Pseudomonas aeruginosa, 13 Strains of Acinetobacter baumannii and 6 Strains of Klebsiella pneumoniae).
Table 4.
Summary of Antibiotic Therapy Prescribed (a) Empirically, and (b) Based on Recommendations from the iACT Service.
Table 5.
Role of Prospective iACT Service in Guiding Antibiotic Combination Therapy.
Table 6.
30-day In-Hospital All-Cause and Infection-Related Mortality, Clinical Response, and Microbiological Eradication Associated with the Type of Infections and Responsible Pathogens.