Table 1.
Summary of the human AH samples from the patients with Coats' disease and the controls without Coats' disease.
Fig 1.
Schematic representation of the workflow of the iTRAQ experiment.
Table 2.
DEPs between the patients with stage 3A, 3B and 4 Coats’ disease and the controls (p < 0.05).
Fig 2.
Representative fundus views of the different stages of Coats' disease, including stage 3A, stage 3B, and stage 4, and the controls.
Fig 3.
Heat map analysis of the differentially expressed proteins between the CK group and three groups of patients with different stages of Coats' disease.
The color scale shown at the top illustrates the relative protein expression level across all the samples. Red represents an expression level lower than the mean, whereas green represents an expression level above the mean.
Fig 4.
Venn diagram indicating the differentially co-expressed proteins (DCPs) from the patients with the three stages of Coats' disease.
The numbers in parentheses indicate the total number of DCPs in stage 3A, stage 3B and stage 4, which are represented by purple, yellow and green, respectively.
Table 3.
Forty-six DCPs, including 29 down-regulated proteins (log FC < -1) and 17 up-regulated proteins (log FC > 1).
Fig 5.
GO annotation and functional classification of the differentially expressed aqueous humor proteins using GO terms for cellular components, molecular functions and biological processes.
Table 4.
GO term classification of the DCPs between the patients and CK with p-values < 0.01.
Fig 6.
Western blotting analyses of 2 DCPs confirmed that the proteins accumulated in three groups of patients.