Table 1.
Subject characteristics (mean ± SD).
Table 2.
Cardiopulmonary exercise data (mean ± SD).
Fig 1.
Representative trace of the transient reduction in minute ventilation in response to breathing 100% oxygen (top).
Mean response to the transient reduction in minute ventilation in response to breathing 100% oxygen in Controls and COPD (Bottom) NOTE: dashed lines correspond to the mean response, * = p<0.05 vs. control.
Fig 2.
Individual ventilatory response to the reduction in arterial saturation in controls (A) and COPD (B), and the mean grouped ventilatory response (ΔVE / ΔSpO2 slope) in controls and COPD (C). NOTE: dashed lines correspond to the mean response, * = p<0.05 vs. control.
Fig 3.
Pulse wave velocity at rest, and during 2 minutes of breathing 100% O2 in controls and COPD patients.
NOTE: p<0.05 vs. control.
Table 3.
Cardiorespiratory responses to one minute of breathing hyperoxia (mean ± SD).
Fig 4.
Regression analysis of the increase in ventilation in response to stepwise reductions in arterial saturation with hypoxia (ΔVE / ΔSPO2 slope) in COPD vs. pulse wave velocity (A), mean arterial pressure (B), VO2peak (C), and Dyspnea (D).