Fig 1.
Representative case of anti-SSB positive patient (right eye of 51 year-old female) who showed abnormally reduced thickness of the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell–inner plexiform layer (mGCIPL).
Color coding is as follows: green = normal range, yellow = below the 5th percentile of normal distribution and red = below the 1st percentile of normal distribution. (A) pRNFL thickness below the 5th percentile in average thickness and in at least one segment of the quadrant was considered as an indicator of abnormally reduced pRNFL thickness. (B) mGCIPL thickness below the 5th percentile in average and minimum thickness and in at least one of six sectors was considered as an indicator of abnormally reduced mGCIPL thickness. The patient showed nonspecific findings in RNFL photo (C) and visual field exam (D).
Table 1.
Demographics and clinical characteristics of study patients.
Table 2.
Comparison of serologic and histopathologic values between pSS patients with normal and abnormal pRNFL or mGCIPL thicknesses.
Table 3.
Factors associated with abnormally reduced pRNFL thickness.
Table 4.
Factors associated with abnormally reduced mGCIPL thickness.
Fig 2.
Scatterplot and linear regression line showing the relationship between OCT measurements and anti-SSB antibodies in patients with primary Sjögren's syndrome.
(A) Average, inferior, and temporal pRNFL thicknesses were significantly correlated with the levels of anti-SSB (P < 0.05). (B) All the parameters of mGCIPL thicknesses were significantly correlated with the anti-SSB levels (P < 0.01).
Fig 3.
Comparison of pRNFL and mGCIPL thicknesses according to anti-SSB positivity in patients with primary Sjögren's syndrome.
(A) Comparison of pRNFL thicknesses between groups. (B) Comparison of mGCIPL thicknesses between groups.