Table 1.
Subject characteristics.
Fig 1.
TBSS results for PIGD patients compared to controls.
Red clusters represent white matter areas with significantly (TFCE-corrected p < 0.05) decreased FA in PIGD patients compared to controls. No such areas were found for TD compared to controls. One representative coronal, sagittal and axial slice are shown with the TBSS results overlain on the mean FA skeleton (in grey).
Fig 2.
Altered white matter tracts in patient subgroups compared to controls.
Tracts identified with probabilistic tractography having increased MD in patient subgroups compared to controls are shown. The red tract connects the left caudate with the contralateral ventral putamen. The blue tract connects the left caudate with the ipsilateral ventral putamen. Both tracts showed increased MD in both patient subgroups compared to controls. The yellow tract connects the right inferior parietal lobule with the right M1 and the green tract connects the right inferior parietal lobule with the right premotor cortex. Both tracts showed increased MD in TD compared to PIGD and controls. Part A shows two sagittal and one axial brain slices where the identified tracts are overlain on the mean FA skeleton. As the yellow and green tract overlap for a large part, only the yellow tract is visible. Part B shows glass brains with 3D representations of the identified tracts.
Table 2.
FA and MD alterations in white matter tracts between PIGD, TD and controls.
Fig 3.
Shape deformations in the left caudate nucleus.
All figures on the left show the left caudate that is color-coded according to p-values. Dark red colors represent p-values above 0.2. Lighter red, orange and yellow represent lower p-values and green colors indicate p-values below 0.95. All figures on the right show a 3D representation of the left caudate with color-coding for the T-values. (A) shows the results of the PIGD-CTRL comparison. (B) shows the results of the PIGD-TD comparison with age correction. (C) shows the results of the PIGD-TD comparison with age and LED correction.