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Fig 1.

Illustration of ROI drawing.

a) WM of bilateral superior frontal gyri; b) WM of bilateral precentral gyri; c) WM of bilateral superior parietal gyri; d) bilateral anterior cingulum; e) fornix, internal capsule and splenium of the corpus callosum; f) genu of the corpus callosum, and WM bilateral occipital; g) superior longitudinal fasciculus.

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Fig 1 Expand

Fig 2.

DWI and FA from a representative subject.

a) b = 0 images; b) DWI images; c) FA maps. Five representative slices are shown from the left to the right.

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Fig 2 Expand

Fig 3.

Scatter plots and regression lines for FA as a function of age.

y-axis is for FA values while x-axis is for age. a) Regression with negative slopes; b) Regression with zero slopes; c) Regression using quadratic models. P values in a) and b) are for testing the hypothesis whether slope = 0; P values in c) are for testing the hypothesis whether linear model is better than quadratic model; PK in c) represents peak positions of the quadratic fit.

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Fig 3 Expand

Table 1.

Statistics of effects of age on regional whiter matter ROIs across the age span for FA.

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Table 1 Expand

Table 2.

Statistics of effects of age on regional whiter matter ROIs across the age span for RD.

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Table 2 Expand

Fig 4.

Scatter plots and regression lines for RD as a function of age.

y-axis is for RD values while x-axis is for age. a) Regression using linear models; b) Regression using quadratic models. P values in a) are for testing the hypothesis whether slope = 0; P values in b) is for testing the hypothesis whether linear model is better than quadratic model; ND in b) represents nadir position of the quadratic fit.

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Fig 4 Expand