Table 1.
Description of the items of the Motor Behavioural Tool.
Table 2.
Increase of the CRS-R subscores in presence of at least one positive MBT item.
Table 3.
Information about individual patient demographics.
CRS-R: Coma Recovery Scale-Revised; DOC: disorders of consciousness; UWS: unresponsive wakefulness syndrome; MCS: minimally conscious state; TBI: traumatic brain injury; IS: ischemic stroke; HS: haemorrhagic stroke; RA: ruptured aneurysm; IVH: intra-ventricular haemorrhage; DAI: diffuse axonal injury; F: frontal; T: temporal; P: parietal; O: occipital; BG: basal ganglia;Mes: mesencephalon; r: right; l: left; b: bilateral.
Table 4.
Statistical characteristics of the patients emerging from DOC compared to the patients remaining in DOC.
P-values corrected for multiple comparison with the Holm-Bonferroni method. ° statistical comparison between UWS patients and MCS patients having emerged from DOC, respectively. DOC: disorders of consciousness; UWS: unresponsive wakefulness syndrome; MCS: minimally conscious state; SD: standard deviation.
Fig 1.
Fitting of the longitudinal CRS-R using the General Linear Modelling.
GLM fitting of the longitudinal CRS-R subscales data; outcome differentiation over time for each subscale between patient emerging from DOC (in blue) and those remaining in DOC (in red); solid lines represent the mean of the time evolution and dash lines represent the superior and inferior bounds of the standard error of the means. Abscissa axe from top to bottom: auditory function scale, visual function scale, motor function scale, oro-motor function scale, communication scale; ordinate axe from left to right: DOC, UWS, MCS. Group distinction not earlier than 19 days according to the various subscales: 20 days for the auditory subscale for all groups of patients; 21 days for the visual subscale; between 19 and 21 days for the motor subscale; between 21 and 22 days for the oro-motor subscale; between 22 and 23 days for the communication subscale. Cut-off scores for the diagnosis of consciousness recovery reached after at least 29 days for the motor function subscale and after at least 40 days for the communication subscale. GLM: General Linear modelling; CRS-R: Coma Recovery Scale-Revised; DOC: disorders of consciousness; UWS: unresponsive wakefulness syndrome; MCS: minimally conscious state.
Table 5.
Statistical prediction of the outcome from the CRS-R scores alone and weighted by the MBT scores (p-values corrected).
Statistical prediction of the outcome from the first CRS-R subscores (auditory, visual, motor and oro-motor functions, and communication subscales) and from the same CRS-R subscores weighted by the MBT clinical values, assessed in the acute phase (mean 11.2 days after brain damage). Prediction proceeded for DOC classes, and for UWS and MCS subclasses. P-values corrected for multiple comparison with the Holm-Bonferroni method. CRS-R: Coma Recovery Scale-Revised; DOC: disorders of consciousness; UWS: unresponsive wakefulness syndrome; MCS: minimally conscious state; MBT: Motor Behavioural Tool.
Table 6.
Statistical prediction of the outcome from the MBT scores.
Statistical prediction of the outcome from the clinical values of the MBT items, assessed in the acute phase at first CRS-R evaluation (mean 11.2 days after brain damage). Prediction proceeded for DOC classes, and UWS and MCS subclasses. Indices of the MBT items refer to the MBT indices presented in Table 1. P-values corrected for multiple comparison with the Holm-Bonferroni method. Sensitivity, specificity and Yule’s Q coefficient not assessed when p-values >.05 of the non-parametric Mann-Whitney U test. DOC: disorders of consciousness; UWS: unresponsive wakefulness syndrome; MCS: minimally conscious state; MBT: Motor Behavioural Tool.