Fig 1.
An example functional run from the blocked emotional stimulus paradigm.
Fig 2.
Region of Interest and fMRI Results—ND Participants.
2a. Anterior cingulate cortex and striatum region of interest (ACC/striatum ROI). 2b. Among ND participants, Ventral and Subgenual regions of the ACC exhibited significantly greater activation to positive versus negative stimuli. 2c. Among ND participants, Rostral ACC showed significantly greater activation to musical versus nonmusical stimuli, while right Caudate showed significantly greater activation to nonmusical versus musical stimuli.
Table 1.
Comparisons of Questionnaire Scores between MDD* and ND† participants.
Table 2.
Whole-brain activations to the emotional auditory functional MRI task, Main effect of Valence—ND Participants.
Table 3.
Whole-brain activations to the emotional auditory functional MRI task, Main effect of Stimulus Type—ND participants.
Table 4.
Whole-brain activations to the emotional auditory functional MRI task, Interaction of Valence by Stimulus Type—ND Participants.
Table 5.
Significant activations within the ACC*/Striatum ROI† –ND participants.
Table 6.
Activations to the emotional auditory functional MRI task, Group Interactions.
Table 7.
Significant activations within the ACC*/Striatum ROI† –Group comparison.
Fig 3.
fMRI Results—Group by Valence.
Rostral and Subgenual ACC showed differential task activation between ND and MDD groups to positive versus negative stimuli. Graphs show mean activation over the entire cluster. Error bars denote standard error.
Fig 4.
fMRI Results—Group by Stimulus Type.
Dorsal ACC showed differential task activation between ND and MDD groups to musical versus nonmusical stimuli. Graphs show mean activation over the entire cluster. Error bars denote standard error.