Fig 1.
The American Joint Committee on Cancer (AJCC) has staged the colorectal cancer based on the anatomical extent of the disease. Stage I: Tumor that is limited to the mucosal layer (T1) or muscularis propria (T2), without involvement of any lymph node or distant metastatic organs. Stage II: Tumor that penetrates the muscularis propria (T3) or invades nearby organs or structures (T4), without involvement of any lymph node or distant metastatic organs. Stage III: Tumor stages with lymph node metastasis but without distant metastasis. Stage IV: Any tumor stage and lymph node status with distant organ metastasis.
Fig 2.
Identification of hub driver genes.
Consensus novel driver genes were identified for each stage from driverDB data. Consensus central genes (‘hubs’) were identified from each stage-specific network. The overlap between these two sets of genes yields ‘hub driver’ genes for each stage.
Table 1.
From tumor genome-sequencing data to network reconstruction.
Fig 3.
Network of cluster centres of stage-II network.
Clustering was done using Moduland.
Table 2.
Centrality analysis of stage-II network.
Table 3.
Moduland decomposition of stage-II network.
Table 4.
GO enrichment analysis of Stage-II network.
Fig 4.
Network of cluster centres of stage-III network.
Clustering was done using Moduland.
Table 5.
Centrality analysis of stage-III network.
Table 6.
Moduland decomposition of stage-III network.
Table 7.
GO enrichment analysis of stage-III network.
Fig 5.
Network of cluster centres of stage-IV network.
Clustering was done using Moduland.
Table 8.
Centrality analysis of stage-IV network.
Table 9.
Moduland decomposition of stage-IV network.
Table 10.
GO enrichment analysis of stage-IV network.