Table 1.
The pharmacokinetic parameters of geniposide, magnolflorine, baicalin, berberine, oroxylin A-7-O-glucuronide, wogonoside, wogonin and oroxylin A in normal and inflamed rats.
Fig 1.
The plasma concentration-time curves of geniposide, magnolflorine, berberine, baicalin, oroxylin A-7-O-glucuronide, wogonoside, wogonin and oroxylin A in normal and inflamed rats.
Fig 2.
The representative concentration and peak area ratio-time curves of the typical components in the plasma from the jugular vein and the pyloric vein of the inflamed rats (I, iridoids; A, alkaloids; F, flavonoids).
Fig 3.
The hepatic clearance rates of the 41 constituents in inflamed rats.
Fig 4.
The levels of the 7 cytokines (IL-6, IL-1β, MIP-2, IFN-γ, TNFα, IL-13 and IL-10) in G3 and G4 rats (pre-m, pre-modeling of inflammation; *P<0.05,**P<0.01, before and after modeling; #P<0.05, ##P<0.01, differences between G3 and G4).
Table 2.
Measurement of the body temperature of G3 and G4 rats (n = 5).
Fig 5.
The average change rate of PK1 (baicalin) with respect to PD1 (IL-6).
The brightness of the colors represents the probability density of the related indexes.
Fig 6.
The relationship between pharmacokinetics and pharmacodynamics.
Each subgraphic represents the change in the trend of a PD index along with a PK index; PK indexes 1–8 represent baicalin, oroxylin A-7-O-glucuronide, wogonoside, geniposide, magnolflorine, berberine, wogonin and oroxylin A, respectively; PD indexes 1–8 represent IL-6, IFN-γ, IL-1β, MIP-2, TNF-α, IL-13, IL-10 and the body temperature of rats, respectively.