Fig 1.
Mid-ventricular short axis native T1 map.
Endocardial (red line) and epicardial (green line) contours, as well as the region-of-interest for the calculation of the average myocardial T1 value (area between the blue lines) can be seen.
Table 1.
Demographic and CMR data.
Table 2.
Comparison of native T1 values and volumetric data between subjects with healthy hearts and patients with distinct cardiac pathologies.
Fig 2.
Native myocardial T1 values in healthy hearts and in several cardiac pathologies.
Average native myocardial T1 values (given as dot plots) observed in the group healthy hearts (HH), coronary artery disease (CAD), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), acute myocarditis (AM), and convalescent myocarditis (CM).
Fig 3.
Native T1 maps (a, d, g) and cine 4-chamber images in end-diastole (b, e, h) and in end-systole (c, f, i) in a subject with a healthy heart (a-c), a patient with hypertrophic cardiomyopathy (d-e), and a patient with acute myocarditis (f-i) presenting with nearly identical slice-averaged T1 values.
Native slice-averaged T1 value (T1), end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and thickness of the interventricular septum (IVS) were as following: subject with healthy heart: T1, 968 ms; EDV, 158 ml; ESV, 58 ml; EF, 63%; IVS, 10 mm; patient with hypertrophic cardiomyopathy: T1, 963 ms; EDV, 74 ml; ESV, 17 ml; EF, 77%; IVS, 21 mm; patient with acute myocarditis: T1, 963 ms; EDV, 236 ml; ESV, 103 ml; EF, 56%; IVS, 11 mm. (The T1 scale extends from 0 ms (black) to 2000 ms (yellow).)
Fig 4.
Comparison of native T1 values between healthy hearts and several myocardial pathologies.
Boxplots and receiver operating characteristic curves, comparing slice-averaged native T1 values between subjects with healthy hearts and all patients with diffuse diseased myocardium, followed by individual comparisons between subjects with healthy hearts and patients with distinct cardiac diseases, can be seen. CAD, coronary artery disease; HCM, hypertrophic cardiomyopathy; DCM, dilated cardiomyopathy; AUC, area under the curve.