Table 1.
RNFL thickness values in controls and MS-patients in all peripapillary sectors and comparison among groups.
Fig 1.
Top left: Example of a peripapillary N-RNFL scan in an ON eye of a 23-year-old MS patient. RNFL thinning is present in the temporal sector and in the PMB (red: below normal limits, green: within normal limits). Top right and below: Boxplots of the global and temporal N-RNFL and ST-RNFL and the PMB N-RNFL values in controls, non-ON eyes, and ON eyes. * indicates a p-value<0.05, generalized estimation equation (GEE) models. RNFL: retinal nerve fibre layer, N-RNFL: peripapillary scan technique with additional examination of the papillomacular bundle, ST-RNFL: standard peripapillary scan technique. G: global, PMB: papillo-macular bundle, T: temporal sector, TS: temporal superior sector, TI: temporal inferior sector, N: nasal sector, NS: nasal superior sector. NI: nasal inferior sector. Correction for multiple group comparisons was performed.
Table 2.
Mean peripapillary RNFL thickness values in all eyes examined (n = 308) across the different anatomical regions and comparison of the measurement obtained with both techniques (N-RNFL and ST-RNFL).
There are no significant differences between the two scanning techniques.
Fig 2.
Comparison of the sensitivity of VEP, OCT, and their combination in all MS eyes with and without previous ON.
A: The sensitivity of VEP is superior to that of OCT (ST-RNFL and N-RNFL). B: Pathologic findings are more frequent in VEP than in OCT for non-ON eyes. RNFL: retinal nerve fibre layer, N-RNFL: peripapillary scan technique with additional examination of the papillomacular bundle, ST-RNFL: standard peripapillary scan technique. ON: optical neuritis, VEP: visual evoked potentials.
Fig 3.
Sensitivity and specificity to detect ON in MS patients.
Abbreviations: N-RNFL: N-sight retinal nerval fibre layer, ST-RNFL: standard retinal nerval fibre layer, PMB: papillo-macular bundle, T: temporal sector, TS: temporal superior sector, TI: temporal inferior sector, G: global, NI: nasal inferior sector, N: nasal sector, NS: nasal superior sector, TI: temporal inferior sector.
Fig 4.
Sensitivity and specificity for detection of MS eyes (n = 73) within all eyes examined (n = 147).
The sensitivity is highest for the RNFL values within the PMB and the temporal sector on N-RNFL and ST-RNFL. Abbreviations: N-RNFL: N-sight retinal nerval fibre layer, ST-RNFL: standard retinal nerval fibre layer, PMB: papillo-macular bundle, T: temporal sector, TS: temporal superior sector, TI: temporal inferior sector, G: global, NI: nasal inferior sector, N: nasal sector, NS: nasal superior sector, TI: temporal inferior sector.
Fig 5.
Agreement of OCT with pathologic VEP findings across all peripapillary sectors with N-RNFL and ST-RNFL.
The highest agreement of OCT and history of ON was for the values within the temporal sector in both N-RNFL and ST-RNFL. Abbreviations: N-RNFL: N-sight retinal nerval fibre layer, ST-RNFL: standard retinal nerval fibre layer, PMB: papillo-macular bundle, T: temporal sector, TS: temporal superior sector, TI: temporal inferior sector, G: global, NI: nasal inferior sector, N: nasal sector, NS: nasal superior sector, TI: temporal inferior sector.