Table 1.
Characteristics of all patients at admission.
Fig 1.
A) Bile acids accumulate in serum of SAM patients compared to controls in discovery cohort. Bar graphs represent mean and standard deviation (SD). Peaks for conjugated and unconjugated CDCA and DCA were indistinguishable and therefore presented as combined values (CDCA/DCA). Significant differences between healthy controls and patients with severe acute malnutrition (SAM) are indicated with stars; * p-value<0.05, ** p-value < 0.01 (Mann-Whitney test). B) Correlation between serum alanine aminotransaminase (ALT) and total bile acids concentrations in serum from the children with severe acute malnutrition of the follow up cohort. Values presented on log-scale. (Spearman correlation = 0.52, p<0.001).
Table 2.
Serum bile acid concentrations in severely malnourished children at admission and prior to discharge in the follow up cohort.
Table 3.
Fecal bile acids concentrations during admission and at Pre-discharge.
Fig 2.
Differences in serum levels of A) FGF19 and B) C4 in children from the follow up cohort at admission and pre-discharge. FGF19 negatively correlates with serum concentration of C4 at C) admission and D) prior to discharge. E) Fecal calprotectin is decreased in children to be discharged. Boxplots represent 25th and 75th quartiles, box-midline indicates median and whiskers define top and bottom values within 1.5 times the inter-quartile range (IQR). Wilcoxon Signed Rank test was used to compare admission and pre-discharge for FGF19 and C4. Mixed effects models were used to test differences in calprotectin to account for missing values. Spearman test was used for correlation. Stars indicate; * p-value < 0.05, ** p-value < 0.01.