Fig 1.
Cluster analysis of temporally expressed entities in peripheral blood leukocytes of Cynomolgus Macaques (all animals) pre-(week 0) or post (weeks 1–6) aerosol-challenge with M. tuberculosis.
These exhibit patterns of up- (cluster 2) or down-regulation (cluster 1) across the six week time course of the experiment. Cluster 2b1 (highlighted) contains co-expressed entities, FOS, IL8 and KLF2.
Fig 2.
Venn Diagram Comparison between Entities Temporarily Expressed at Different Weekly Timepoints from the T478 feature set.
Fig 3.
Cellular pathway map of key regulatory entities at the two to four week time-points.
Heatmaps for each entities showing expression of key entities from microarray analyses across all animals in the study.
Fig 4.
Cluster analysis of Type II Interferon-related entities in NHPs of Chinese or Mauritian origin.
Table 1.
Fold change values of the most highly statistically-significant, differentially regulated qPCR validated entities.
Fig 5.
Cluster analysis of statistically significant, validated entities in qPCR datasets; segregated Chinese and Mauritian Cynomolgus Macaque groups.
Fig 6.
Network inference map results from the T50 VS dataset across both CN and MN NHP groups, visualised using Cytoscape.
Blue arrows indicate negative influence effects and red arrows positive regulatory effects of increasing intensity represented by the thickness of the line.
Table 2.
Gene entities from comparison of NHP and human parametric ANOVA analyses.
Thirty-one features corresponding to 30 discrete gene entities were found to be shared between Cynomolgus Macaque and two human data sets. These are ranked from lowest to highest using composite p value.