Table 1.
Subject Characteristics.
Fig 1.
Effect of exercise intensity on plasma glucose, insulin, C-peptide and FFA.
FFA = free fatty acids. *Compared to Control, P<0.05. ^Compared to MIE, P<0.05.
Table 2.
Area under the curve from the OGTT before and after exercise at different intensities.
Fig 2.
Effect of exercise intensity on multi-organ insulin resistance.
Data are expressed as mean ± SEM. OMM = oral minimal model was calculated from plasma glucose and insulin to measure skeletal muscle insulin resistance. Homeostatic model of insulin resistance (HOMR-IR) was calculated as fasting PG x fasting PI to depict hepatic insulin resistance. Adipose-IR was calculated as fasting FFA x fasting PI to determine adipose insulin resistance. *Compared to Control, P<0.05. ^Compared to MIE, P<0.05.
Fig 3.
Effect of exercise intensity on glucose-stimulated insulin secretion.
Data are expressed as mean ± SEM. ISR = insulin secretion rate derived from deconvolution of plasma C-peptide. GSIS = glucose-stimulated insulin secretion rate (ISR; total AUC C-peptide divided by total AUC Glucose). *Compared to Control, P<0.05.
Fig 4.
Effect of exercise intensity on β-cell function.
Data are expressed as mean ± SEM. DI = disposition index and was used to characterize pancreatic β-cell function. Skeletal muscle DI was calculated as AUC of ISR/Glucose x oral glucose minimal model. Hepatic DI was estimated as AUC of ISR/Glucose x HOMA-IR. Adipose DI was determined as AUC of ISR/Glucose x Adipose-IR. *Compared to Control, P<0.05. ^Compared to MIE, P<0.05.