Table 1.
Study inclusion and exclusion criteria.
Table 2.
Numbers of local and central ethics committees approvals for all participating sites.
Fig 1.
Flowchart of the enrolled patients.
Table 3.
Characteristics of studied population.
QRS morphology was classified according to AHA/ACCF/HRS guidelines. Patient aetiology other means inflammation induced cardiomyopathy.
Fig 2.
Regression curve constructed through percentage LV+dP/dtmax changes during each configuration depending on AV delay in one patient.
Red dot indicates calculated maximal average response at AV-best. AV = 0 indicates AV-delay calculated by CardioSyncTM formula. AV-delay delta stands for change from AV-delay calculated by CardioSyncTM formula in ms.
Fig 3.
Boxplot of LV+dP/dtmax % increase for the different configurations.
Distal, mid and prox denote LV-electrode position on the LV-lead. MultiSPOT denote pacing on all three LV-electrode positions simultaneously. Solid line depicts mean value and boxes are 75 and 25 percentiles. Whiskers represent 2.5 and 97.5% percentiles.
Fig 4.
Individual contractility data per patient.
Presented are the maximal % LV+dP/dtmax values (mean and confidence intervals) for all 24 patients for all different BiV and MultiSPOT configurations. Patient 6 has no LV-distal data because of intolerable phrenic nerve stimulation at this position. For more explanation see text.
Fig 5.
QRS width values at different pacing modes.
QRS-width reduction by BiV pacing approximates 15% and is only slightly more reduced by MultiSPOT pacing. It has weak correlation with % LV+dP/dtmax increase (R = -0.136). (B)
Fig 6.
QLV/QRS values upon different pacing modes.
Normalized QLV/QRS values for the different electrodes on the Multi-electrode LV lead.Data and correlations are presented as mean±SD. * indicates significant different from MultiSPOT.