Fig 1.
Example of fd-OCT generated macular full-thickness measurements of the right eye.
The green rectangle demarcates the scanned area (6x6mm). The nine macular full-thickness sectors were based on Early Treatment Diabetic Retinopathy Study map.
Fig 2.
Example of fd-OCT-generated inner macular thickness measurements.
Left: scanned area (7x7 mm). The inner retinal layers thickness measurements are show in each 10x10 grid cells. The total analyzed area corresponded to 6x6 mm. Right: horizontal fd-OCT B scan through the fovea. The green lines correspond to the boundaries of the inner retinal layers identified during the segmentation process. The first row represents macular RNFL (mRNFL) thickness measured from the internal limiting membrane (ILM) to the inner boundary of the ganglion cell layer (GCL). The second row represents GCL + inner plexiform layer (IPL) thickness measured from the inner boundary of the GCL to the outer boundary of the IPL (GCL+). The third row represents mRNFL + GCL + IPL measured from the ILM to the outer boundary of the IPL (GCL++).
Table 1.
Demographic characteristics of AD patients and healthy controls.
Table 2.
Mean values (SD) of frequency domain optical coherence tomography parameters of peripapillary RNFL thickness and full and inner macular thickness (in μm), with areas under the receiver operating characteristic curves (AUC) and sensitivities at fixed specificities.
Fig 3.
Scatter plots of MMSE scores plotted against fd-OCT measurements of the 4 inner macular segments.
The parameters with the strongest correlation were selected.
Table 3.
Relationship between fd-OCT parameters and mini-mental state examination (MMSE) scores.