Table 1.
Demographic data in all study participants.
Fig 1.
Representative cases of perimetric group and preperimetric group in patients with pituitary adenoma.
(A) The patient was a 42-year old female with a characteristic bitemporal defect on visual field (VF) examination. Macular ganglion cell analysis (GCA) revealed a preferential ganglion cell and inner plexiform layer thinning in bi-nasal area in the GCA thickness, deviation and sector maps. (B) The patient was 58-year old male without any VF defects. Also, temporal circumpapillary retinal nerve fiber layer thinning was found only in his right eye. However, GCA revealed a characteristic bi-nasal pattern respecting the vertical meridian in both eyes.
Fig 2.
Comparison of the area under the receiver operating characteristic curves (AUC) of the macular ganglion cell and inner plexiform layer (mGCIPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness for discriminating preperimetric pituitary adenoma group from the normal control group.
The AUC of the mGCIPL thicknesses in inferonasal and superonasal area were significantly greater than those of cpRNFL thicknesses (P < 0.001). Of the GCIPL-related parameters, the mGCIPL thickness in inferonasal area showed the greatest AUC value (0.965), followed by the mGCIPL thickness in superonasal area (0.958).
Fig 3.
Comparison of the reduction rate of macular ganglion cell-inner plexiform layer (mGCIPL) thicknesses among sectors in the pituitary adenoma (PA) groups.
The higher reduction rate of the mGCIPL thickness was noticed in nasal sector compared to other sectors, irrespective of the presence of temporal visual field defect. (P < 0.001) Perimetric PA eyes exhibited higher reduction rate in all sectors than preperimetric PA eyes (P < 0.001 for superonasal, inferonasal, and superior sectors; P = 0.001 for inferior sector; P = 0.004 for interotemporal sector).
Table 2.
cpRNFL and mGCIPL thickness measurements in the participants.
Table 3.
Comparison of the area under the receiver operating characteristic curves (AUC) between control and preperimetric PA group.
Table 4.
Comparison of detection rate of an abnormal color code using a GCA sector map in 46 patients with pituitary adenoma.
Table 5.
Comparison of detection rate of an abnormal color code using a GCA sector map between PA group and VF- matched NTG group.