Fig 1.
Application of the time-signal intensity curve and the kinetic curve in breast MRI analysis.
(a) MRI of a 58-year-old female showed an invasive ductal carcinoma on the upper outer quadrant of the left breast. The green circle indicates the region of interest (ROI) that was used for estimating the change in the C1 value, and the red circle represents the ROI for measuring the ΔM. (b) The blue line is the time-signal intensity curve, and the orange line was generated from a plot of the C2 values to form a kinetic modeling curve.
Fig 2.
Linear regression analysis for the correlation between blood flow and phase time.
Table 1.
The findings of the breast lesions from three radiologists based on the time-signal intensity curve and the kinetic curve.
The sensitivity (SN), specificity (SP), area under the receiver operating characteristic curve (AUC), positive predictive value (PPV), negative predictive value (NPV), and kappa (κ) value are presented.
Fig 3.
Comparison of the area under the ROC obtained by three radiologists using two different methods.
Table 2.
Percentages of benign and malignant Type 1 (persistent enhancing), Type 2 (plateau) and Type 3 (washout) lesions diagnosed by three radiologists based on the time-signal intensity curve and the kinetic curve.