Fig 1.
Predicted probability of MAC reduction obtained by logistic regression (line) of observed responses (closed circles) to noxious electrical stimulation in chickens anesthetized with various end-tidal concentrations of isoflurane (presented as % change from their individual isoflurane MAC), following intramuscular administration of 3 (n = 9) or 6 (n = 12) mg kg-1 methadone.
A—Data obtained 15 minutes after IM administration of 3 mg kg-1 methadone. B—Data obtained 15 minutes after IM administration of 6 mg kg-1 methadone. C—Data obtained 30 minutes after IM administration of 6 mg kg-1 methadone. D—Data obtained 45 minutes after IM administration of 6 mg kg-1 methadone. The closed square shows the predicted MAC reduction (the label represents the value in %), and the error bar represents the 95% Wald confidence interval. The 95% confidence interval does not include 0 for the 6 mg kg-1 group at 15 min only, and MAC reduction was therefore considered significant only in that group at that time point. Note that some data points may be superimposed.
Table 1.
Temperature and selected cardiorespiratory variables in hens anesthetized with isoflurane at baseline (measurement obtained at time points used for MAC determination, i.e. at isoflurane concentration close to 1.0 MAC), 15 minutes after IM administration of 3 mg kg-1 methadone, and 15, 30 and 45 minutes after IM administration of 6 mg kg-1 methadone.
Table 2.
Mean ± SD cardiorespiratory, acid-base and arterial electrolyte variables in hens anesthetized with isoflurane at 1.0 MAC (T1MAC), and at 0.7 MAC before (T0.7MAC) and after IM methadone (6 mg kg-1) administration (T1 to T45).