Table 1.
Characteristics of eligible studies in the meta-analysis of PD-1 polymorphisms and cancer risk.
Table 2.
Quality assessment based on the Newcastle-Ottawa Scale of studies included in this meta-analysisa.
Fig 1.
Flow diagram of study selection.
Fig 2.
Forest plots of the PD-1.5 (rs2227981) polymorphism and cancer risk for overall populations (A for TT vs. CC; B for TT vs. CT+CC; C for TT+CT vs. CC; D for TC vs. CC and E for T vs. C).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Fig 3.
Forest plots of the PD-1.5 (rs2227981) polymorphism and cancer risk for Asians subgroup (A for TT vs. CC; B for TT vs. CT+CC; C for TT+CT vs. CC; D for TC vs. CC and E for T vs. C).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Fig 4.
Forest plots of the PD-1.5 (rs2227981) polymorphism and cancer risk for population-based subgroup (A for TT vs. CC; B for TT vs. CT+CC; C for TT+CT vs. CC; D for TC vs. CC and E for T vs. C).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Fig 5.
Forest plots of the PD-1.9 (rs2227982) polymorphism and cancer risk for overall populations (A for TT vs. CC; B for TT vs. CT+CC; C for TT+CT vs. CC; D for TC vs. CC and E for T vs. C).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Fig 6.
Forest plots of the PD-1 rs7421861 polymorphism and cancer risk for overall populations (A for CC vs. TT; B for CC vs. CT+TT; C for CC+CT vs. TT; D for CT vs. TT and E for C vs. T).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Fig 7.
Forest plots of the PD-1.3(rs11568821) polymorphism and cancer risk for overall populations (A for AA vs. GG; B for AA vs. AG+GG; C for AA+AG vs. GG; D for AG vs. GG and E for A vs. G).
The squares and horizontal lines correspond to the study-specific ORs and 95% CIs. The areas of the squares reflect the study-specific weights (which was the inverse of the variance). The diamonds represent the pooled ORs and 95% CIs.
Table 3.
Characteristics and results of the present study compared with the previous meta-analysis.
Table 4.
Summary of meta-analyses of PD-1 polymorphisms and cancer risk.