Fig 1.
Localization in SERPINC1 gene of potential vitamin D response elements (VDRE) identified by using in silico predictions with JASPAR software.
The localization in SERPINC1 of the genetic variations evaluated in this study is shown. The predictive score of interaction with RXRα/VDR of wild type and mutated sequences obtained by using JASPAR software are also indicated.
Table 1.
Demographic, clinical, analytical and genetic features of patients with antithrombin deficiency and mutations affecting potential regulatory sequences in SERPINC1.
Fig 2.
Effect of paricalcitol, a vitamin D analog, on HepG2 cells.
A) RNA expression levels of SERPINC1 and VDR. B) Western blot analysis of antithrombin and prothrombin secreted to the conditioned medium.