Fig 1.
Schematic diagram outlining the fate of glycerophospholipid following hydrolysis by sPLA2-IIA.
Hydrolysis by sPLA2-IIA results in production of LPC and AA, which leads to generation of various pro-inflammatory metabolites. Abbrev: LPC, lysophosphotidylcholine; LysoPLD, lysophospholipase D; LPA, lysophosphatidic acid; COX, cyclooxygenase; PGG2, prostaglandin G2; PGHS, prostaglandin H synthase; PGH2, Prostaglandin H2; PGs, prostaglandins; PGE2, prostaglandin E2, PGF2α, prostaglandin F2α; PGD2, prostaglandin D2; PGI2, prostaglandin I2 also known as prostacyclin; HPETE, 5-hydroperoxyeicosatetraenoic acid; HETE, Hydroxyicosatetraenoic acid; TXAs, thromboxanes.
Table 1.
Demographic data of recruited patients.
Table 2.
Bacterial aetiology as detected via Cultivation.
Fig 2.
Box-plot for CD64 levels in sepsis and non-sepsis diagnosis.
abc = antigen bound cell. Boxes show the 25th-75th centiles, while whiskers indicate the 10th and 90th centiles. Horizontal lines within the boxes indicate the median. Outliers are shown as circles.
Fig 3.
Box-plot for CD64 levels in bacterial and non-bacterial infection diagnosis.
abc = antigen bound cell. Boxes show the 25th-75th centiles, while whiskers indicate the 10th and 90th centiles. Horizontal lines within the boxes indicate the median. Outliers are shown as circles and stars.
Table 3.
CD64 and sPLA2-IIA expression for recruited patients.
sPLA2-IIA = Group IIA secretory phospholipase A2; abc = antigen bound cell; AUC = area under the curve; Sn = Sensitivity; Sp = Specificity; PPV = positive predictive value; NPV = negative predictive value; CI = Confidence Interval.
Fig 4.
Box-plot for sPLA2-IIA levels in sepsis and non-sepsis diagnosis.
Boxes show the 25th-75th centiles, while whiskers indicate the 10th and 90th centiles. Horizontal lines within the boxes indicate the median. Outliers are shown as circles.
Fig 5.
Box-plot for sPLA2-IIA levels in bacterial and non-bacterial infection diagnosis.
Boxes show the 25th-75th centiles, while whiskers indicate the 10th and 90th centiles. Horizontal lines within the boxes indicate the median. Outliers are shown as circles.
Fig 6.
ROC curves for CD64 and sPLA2-IIA in sepsis diagnosis.
abc = antigen bound cell.
Fig 7.
ROC curves for CD64 and sPLA2-IIA in bacterial infection diagnosis.
abc = antigen bound cell.