Fig 1.
CONSORT table.
Table 1.
Details of patients.
Fig 2.
Plasma levels of Heparin binding protein on admission to intensive care and the following two days for patients with an arterial PaO2/Fraction of inspired O2 of more than 27 kPa (left) or less than 27 kPa (right) on the last registration.
Values at admission are significantly higher in patients with PaO2/Fraction of inspired O2 < 27 (p<0,001). Square, box and bracket indicates mean, standard deviation and 95% confidence interval. * = statistical difference between groups p < 0,05.
Fig 3.
Plasma levels of Heparin binding protein on admission to intensive care and the following two days for patients with circulatory subscore of SOFA less than 4 (left) or 4 (right) on the last registration.
Circulatory SOFA indicates circulatory subscore of Sequential organ failure assessment. Values at admission are significantly higher in patients with a circulatory subscore of 4 (p<0,001). Square, box and bracket indicates mean, standard deviation and 95% confidence interval. * = statistical difference between groups p < 0,05.
Table 2.
Patient data in relation to organ failure at last registration (maximum 72 hours after admission).
Table 3.
Patient data in relation to mortality (at 30 days from admission).
Fig 4.
Heparin binding protein (HBP) concentration at admission in the different groups.
Log admission-HBP was higher in the group with severe sepsis when compared with the groups ‘other medical’ (p = 0.009) and ‘trauma with TBI’ (p = 0.013). Square, box and brackets indicate median, IQR and non-outlier range. There are three extreme outliers in the severe sepsis group that are not shown (out of range of Fig). (TBI = Traumatic brain injury).
Fig 5.
ROC curves for sensitivity and specificity of plasma levels at admission of Heparin binding protein for a P:F ratio of < 27 at last registration (A), for a circulatory subscore of SOFA of 4 at last registration (B) and for 30-day mortality (C).