Fig 1.
Locations of the five ACC sub-regions, which are labeled by red circles.
Labels 1 to 10 indicate, respectively, the left caudal ACC, dorsal ACC, rostral ACC, perigenual ACC, and subgenual ACC, and the right caudal ACC, dorsal ACC, rostral ACC, perigenual ACC and subgenual ACC respectively. L, left; R, right; ACC, anterior cingulate cortex.
Table 1.
MNI coordinates of the five ACC sub-regions.
Fig 2.
Functional connectivity maps of five ACC sub-regions for the ASD group and the healthy control group, corrected for multiple comparisons.
The maps were corrected for multiple comparisons using Gaussian random theory with q < 0.05 (voxel p < 0.01, z > 2.3). The left panel (labels A to E) shows the functional connectivity maps of the caudal ACC, dorsal ACC, rostral ACC, perigenual ACC, and subgenual ACC in the autism group. The right panel (labels A to E) shows the functional connectivity maps of the right five ACC sub-regions in HC group. HC, healthy control; ACC, anterior cingulate cortex.
Fig 3.
Functional connectivity maps of the five ACC sub-regions for the ASD group and the healthy control group, based on thresholding.
Maps of the left five ACC sub-regions and the right five ACC sub-regions in the HC group (A, B) and the autism group (C, D), using a threshold of |t| > 15. The brain areas with different colors indicate the mask where the voxels survived the threshold.
Fig 4.
Brain regions showing significant differences in the functional connectivity of the left caudal ACC in the autism group compared with the healthy control group.
Brain regions showing significant differences in functional connectivity of the left caudal ACC in persons with autism compared with the healthy controls. The blue color indicates decreased functional connectivity in the autism group. FC, functional connectivity; ACC, anterior cingulate cortex.
Table 2.
Functional connectivity alterations of the left caudal ACC in the autism group (n = 209) compared with the healthy control group (n = 238).
Fig 5.
Correlation between altered functional connectivity and Stereotyped Behaviors and Restricted Interests (SBRI) scores in the autism group.
Altered functional connectivity (z-scores) between the left caudal ACC and right insula were significantly correlated with SBRI scores in the autism group. ACC, anterior cingulate cortex.
Table 3.
Pearson correlations between functional connectivity (z-scores) and clinic variables in the autism group.