Table 1.
Clinical, biochemical, renal and PD parameters in 37 non-diabetic patients in PD at baseline and during the 3 years of the study.
Fig 1.
FGF-21 plasma level variation over time.
FGF-21 plasma level variation over time in the 48 studied patients, according to the presence or absence of diabetes. The significant increase in the first year affecting both non-diabetic and diabetic patients is remarkable. After this period, FGF-21 levels remained approximately 3-fold over the initial range for 3 years in the non-diabetic patients. Abbreviations: DM: diabetic patients; Non-DM: non-diabetic patients. *p<0.05 (Linear Mixed-Effects Regression Model).
Table 2.
Matrix correlation between clinical and analytical parameters with FGF-21 at baseline, and at the first year.
Correlation of increment during the first year in clinical and analytical parameters with FGF-21 increment, in non-diabetic patients.
Table 3.
Natural History of napierian logarithm of FGF-21 plasma levels in PD patients estimated by the random linear time model.
Table 4.
Estimation of the relationship between FGF-21 and glucose homeostasis, residual renal function and peritoneal functional parameters adjusted over time.
Fig 2.
Contour plot representing the evolution of plasma FGF-21 levels over time in PD therapy, according to residual renal function.
Contour plot representing the evolution of plasma FGF-21 levels (scaled by a Napierian logarithm on the y-axis) over time in PD therapy, according to residual renal function (RRF). The quantitative color scheme was chosen in a log scale (blue = the lowest, red = the highest) to achieve optimal range in the display; the annotated color quantitative scale shows the 95% confidence interval for the values.
Fig 3.
Contour plot representing the association between plasma FGF-21 levels, peritoneal protein losses and time on PD.
Contour plot representing the independent association between plasma FGF-21 levels (Napierian logarithm) represented by the blue lines, peritoneal protein losses (Y-axis) and time on PD (X-axis). This contour plot indicates the FGF-21 value expected according to time on PD and peritoneal protein losses.