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Fig 1.

Study flow diagram.

Note: CVD, cardiovascular disease; RA, rheumatoid arthritis; SID, supportive information for rheumatoid arthritis diagnosis.

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Table 1.

Characteristics* of individuals with and without rheumatoid arthritis.

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Fig 2.

Adjusted incidence rate ratios for the association between rheumatoid arthritis and the initial presentation of twelve cardiovascular diseases.

[Fig note: CI, confidence interval; CVD, cardiovascular disease; IRR, incidence rate ratios; n, number of events. CVD risk factors included index of multiple deprivation, smoking status, systolic blood pressure, body mass index and diabetes. All patients with rheumatoid arthritis (regardless of disease duration) are included. Because of the limited number of events, estimates for cardiac arrest, subarachnoid haemorrhage, intracerebral haemorrhage and abdominal aortic aneurysm are adjusted for sex, age, index of multiple deprivation, smoking and diabetes. CVD medications included use of blood pressure and lipid lowering medication. Anti-inflammatory medication included nonsteroidal anti-inflammatory drugs and oral corticosteroids.]

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Table 2.

Incidence of the initial presentation of twelve cardiovascular diseases with 95% confidence interval in individuals with and without rheumatoid arthritis.

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Table 2 Expand

Fig 3.

Adjusted incidence rate ratios of the initial presentation of twelve cardiovascular diseases for incident and prevalent rheumatoid arthritis (vs. non-rheumatoid arthritis).

[Figure note: CI, confidence interval; IRR, incidence rate ratios adjusted for sex, age, index of multiple deprivation, smoking status, systolic blood pressure, body mass index and diabetes (or rheumatoid arthritis). Because of the limited number of events, estimates for cardiac arrest are not adjusted for body mass index; and estimates for subarachnoid haemorrhage, intracerebral haemorrhage and abdominal aortic aneurysm are adjusted for sex, age, index of multiple deprivation, smoking and diabetes (or rheumatoid arthritis).]

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