Table 1.
Number of cases of oral (oropharyngeal and oral cavity) squamous cell carcinoma among ages 0–84 between 1973–2012 by race and cancer subsite group.
Fig 1.
Schematic of the two-stage clonal expansion model with period and cohort dependencies.
Fig 2.
Age-adjusted incidence rates of oral squamous cell carcinoma among ages 30–84 by cancer subsite group: (a) HPV-related, (b) HPV-unrelated, and (c) oral tongue.
Please note the change in axes scale for the oral tongue cancer.
Fig 3.
Incidence rates of oral squamous cell carcinoma among white males for HPV-related, by cohort (a) and period (b), and HPV-unrelated subsite groups, by cohort (c) and period (d).
Fig 4.
Fits of the two-stage clonal expansion model with period and cohort effects on initiation to incidence rates of oral squamous cell carcinoma among white males for HPV-related subsites, by cohort (a) and period (b), and HPV-unrelated subsites, by cohort (c) and period (d).
The dots are SEER data, and lines are model fits.
Fig 5.
Hazard, cohort effects, and period effects for the cohort-and-period-effects-on-r APC—TSCE models of oral squamous cell carcinoma by race and cancer subsite group.
(a) HPV-related hazards. (b) HPV-unrelated hazards. (c) Oral tongue hazards. (d) HPV-related cohort effects. (e) HPV-unrelated cohort effects. (f) Oral tongue cohort effects. (g) HPV-related period effects. (h) HPV-unrelated period effects. (i) Oral tongue period effects.
Table 2.
Biological parameters for the period-and-cohort-on-r APC—TSCE models of oral squamous cell carcinoma by race and cancer subsite group with 95% Wald confidence intervals.